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Confusion, depression, hallucinations, thoughts of suicide worsening of involuntary movements spasms. Possible side effects of Sinemet All medicines may cause side effects, but many people have no, or minor, side effects. Daily dosage of Sinemet should be chosen that will provide approximately 25 of the previous levodopa dosage. Pregnancy Although the effects of SINEMET on human pregnancy are unknown both levodopa and combinations of carbidopa and levodopa have caused kad sinemet pigiai visceral and skeletal malformations in rabbits see Animal Teratology and Reproductive Studies. Were the most frequently reported treatment-emergent adverse events.